The Adult Immune Response Study
- 20 healthy volunteers received a supplement comprising 25 billion Lab4 probiotics and 2g of fructooligosaccharide (FOS) daily for 12 weeks.
- Blood samples were collected at the start, 6 and 12 weeks.
- Peripheral blood mononuclear cells (PBMCs) were isolated from the blood samples and cultured ex-vivo in the absence (‘resting’) or presence (challenge) of lipopolysaccharide (bacterial toxin).
In the ‘resting’ immune state:
- Significant enhancement of production of the anti-inflammatory cytokines IL-10 and TGF-β over the 12 week period (**P<0.0001)
During challenge with bacterial toxin:
- Significant decrease in production of the pro-inflammatory cytokines IL-6 and IL-1β(*P<0.01,**P<0.0001)
Hepburn NJ et al. 2013
Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals.
Beneficial Microbes 4(4): 313-17