Cambridge Probiotic & Antibiotic Trial 1
This randomised, double blind, placebo-controlled study investigated the effect of Lab4 probiotic supplementation on the gut microbiota composition and prevention of pathogenic microorganisms overgrowth in response to antibiotic therapy.
• The study was carried out at Addenbrooke’s Hospital in Cambridge.
• 22 patients requiring antibiotic therapy were divided into three groups
• Stool analysis was then conducted over a 28-day period to assess the different populations of bacteria in the gut microbiota.
- The total numbers of facultative anaerobes:
- significantly increased in the patients on antibiotics and placebo at the end of the antibiotic treatment (*P<0.05) and remained increased post antibiotic therapy (*P<0.05) (Group 1).
- significantly increased in the patients on antibiotics and placebo at the end of the antibiotic treatment (*P<0.05), but the numbers decreased significantly after introducing Lab4 probiotic supplementation post antibiotic (*P<0.05) (Group 2).
- remained stable in the patients on antibiotics and Lab4 probiotics throughout the study period (Group 3).
Madden JAJ et al 2005. Effects of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study.
Int Immunopharmacology 5:1091-1097